Nowadays, there has been a considerable advance of personalized medicine on a scientific basis and clinical demands in cardiovascular diseases. This study investigated a history of coronary artery bypass graft surgery a strong determinant of inferiority of organ in cadaveric liver donation.
Personalized medicine is a new medical model with whole determinations and practices being appropriate to individual patients in whatever ways feasible. Significant advances in cadaveric organs utilization have provided a sturdy foothold for establishment of organ donation programs from extended criteria donors (ECD). However, these donors are still being neglected in many developing countries. Although the livers procured from ECDs may be problematic somehow, the high rate of death in waiting list has made specialists to come up with the hard decisions of accepting the risks. It is shown that marginal livers perform inferior defense to ischemia/reperfusion injury, which is responsible for graft dysfunction in ECD organs. On the other hand, liver steatosis makes the organ more prone to ischemia/reperfusion injury. Outcome of fatty livers after transplantation has been shown to be under influence of severity of steatosis and donor age according to scoring systems. In addition to liver cells degeneration, harmful impact of global atherosclerosis on arteries and complications of calcified plaques during surgery should be under focus. In contrast, despite broader utilization of ECD livers, discard rate of donors in our OPU after liver biopsy has been decreased due to gaining from systematic and scheduled donor management strategies. This study investigated a history of coronary artery bypass graft surgery a strong determinant of inferiority of organ in cadaveric liver donation.
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